The meaning of the phrase "a leopard can't change it's spots" is that a person cannot change his or her basic nature no matter how hard they try.
The King James Bible, Jeremiah 13:23 reads: "Can the Ethiopian change his skin, or the leopard his spots? Then you also can do good, Who are accustomed to doing evil."
Use Example - Stephanie knows better than to trust Bill; he always was a liar and a leopard can't change it's spots.
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Animal Unchangeable